Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision

Starting soon · Not applicable

Conditions studied: Tracheal Stenosis

In brief

Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe. Doctors often treat this by using a bronchoscope-a thin, flexible tube with a camera-to open up the airway or remove scar tissue. While these procedures help patients breathe better, we do not fully understand why the narrowing occurs or how the tissue heals afterward. The purpose of this study is to better understand the biological changes in the airway tissue before and after these standard medical procedures. During the procedure, small samples of tissue that would already be collected as part of normal care will be analyzed in the laboratory. The results may help doctors learn more about airway healing and could guide better treatments in the future.

Key facts

Study ID

NCT07463742

Run by

University of Maryland, Baltimore

People needed

40

Starts

2026-05-01

Expected to finish

2032-05-01

Last updated by the study team

2026-03-16

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• symptomatic tracheal stenosis
• idiopathic subglottic stenosis
• iatrogenic tracheal stenosis from intubation or tracheostomy

You may not qualify if…

• positive ANA or ANCA
• tracheal stenosis from infection, i.e. TB
• tracheal stenosis with cartilage fracture
• tracheal stenosis with malacia
• tracheal stenosis from malignancy
• tracheal stenosis from benign tumor
• presence of glottic or supraglottic stenosis

Where it is running

• University of Maryland — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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