The Influence of Anemia on HbA1c Readings in Non-Diabetic Patients

Starting soon

Conditions studied: Anemia, HbA1c

In brief

The goal of this observational study is to learn about the effects of different types of anemia on HbA1c test results in non-diabetic adults who have anemia but do not have diabetes. The main question it aims to answer is: \- Do different types of anemia (iron deficiency, vitamin B12/folate deficiency, thalassemia, and anemia of chronic illness) cause HbA1c levels to be falsely high or low in people without diabetes?

Key facts

Study ID

NCT07463612

Run by

Sohag University

People needed

100

Starts

2026-03-01

Expected to finish

2026-06-01

Last updated by the study team

2026-03-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult participants aged 18 years and above.
• Non-diabetic individuals, defined as:
• Fasting plasma glucose < 126 mg/dL and/or
• HbA1c < 6.5%, with no prior diagnosis of diabetes mellitus.
• Individuals diagnosed with anemia based on WHO criteria:
• Hemoglobin < 13 g/dL in males
• Hemoglobin < 12 g/dL in female
• Patients with hemolytic anemia including thalassemia ( thalassemia trait and intermediate ) , sickle cell ( trait and disease ).
• Patients with confirmed specific types of anemia, based on laboratory evaluation:
• Iron deficiency anemia
• Vitamin B12 deficiency anemia
• Folate deficiency anemia
• Anemia of chronic diseases

You may not qualify if…

• Known cases of diabetes mellitus or prediabetes.
• Recent blood transfusion within the last 3 months.
• Use of medications known to affect HbA1c levels
• Acute illness or infection at the time of enrollment.
• Pregnant women
• Hematological malignancies

Where it is running

• Sohag University Hospitals — Sohag, Sohag Governorate, Egypt

Full record on ClinicalTrials.gov

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