Suzetrigine for Non-Mastectomy Breast Surgery

Enrolling by invitation · Phase 4

Conditions studied: Pain, Acute Postoperative, Breast Disease

In brief

This is a single-center clinical study to investigate the efficacy of a Food and Drug Administration-approved analgesic, suzetrigine, to treat pain following non-mastectomy breast surgery in concert with a single-injection paravertebral nerve block.

Key facts

Study ID

NCT07463430

Run by

University of California, San Diego

People needed

120

Starts

2026-04-14

Expected to finish

2027-12-31

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult participants of at least 18 years of age
• Undergoing uni-or bilateral surgical procedures of the breast(s) anticipated to result in at least moderate pain (NRS > 3)
• Planned single-injection peripheral nerve block(s)

You may not qualify if…

• Chronic opioid or tramadol use (daily within prior 2 weeks and duration > 4 weeks)
• Neurological deficit of the surgical area
• History of opioid misuse or dependence
• Renal impairment with a GFR<15
• Hepatic impairment (Child-Pugh Class B or C)
• Use of a moderate or strong CYP3A inhibitor in the week before or plan for use the week after surgery
• Current use of hormonal contraceptive containing progestins other than levonorgestrel and norethindrone, physiologic potential for pregnancy, anticipated sexual activity within the first postoperative month, and unwillingness to use additional nonhormonal contraception
• Incarceration
• Pregnancy
• Inability to contact the investigators during the treatment period, and vice versa (e.g., lack of telephone access)

Where it is running

• University of California San Diego — San Diego, California, United States

Full record on ClinicalTrials.gov

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