High-Risk Transcriptome Molecular Prediction Study of MASH-Associated Colorectal Polyps
Recruiting now
Conditions studied: MASH - Metabolic Dysfunction-Associated Steatohepatitis
In brief
The goal of this observational study is to learn about the molecular characteristics of colorectal polyps in patients with metabolic dysfunction-associated steatohepatitis (MASH) compared to individuals without fatty liver, and to identify potential transcriptomic biomarkers for high-risk polyps. The main questions it aims to answer are: What are the key gene expression differences in adenomatous polyps between MASH patients and non-fatty liver individuals? Can specific high-risk transcriptional molecules in plasma and polyp tissue serve as biomarkers for MASH-related colorectal polyps? Participants already scheduled for colonoscopic polypectomy as part of their routine care will provide a small portion of their polyp tissue, residual plasma from standard blood tests, and allow use of their stored pathological slides for research; they will also be followed up every six months.
Key facts
- Study ID
- NCT07463287
- Run by
- Shanghai East Hospital
- People needed
- 100
- Starts
- 2025-04-30
- Expected to finish
- 2027-04-30
- Last updated by the study team
- 2026-03-11
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of MAFLD conforms to the "Guidelines for the Prevention and Treatment of Non-alcoholic Fatty Liver Disease" (2018 Edition);
- Male or female patients aged 18-70 years;
- Signed informed consent form and explanation of the specific study protocol.
You may not qualify if…
- Chronic liver disease due to other etiologies (alcoholic, viral, autoimmune, drug-induced, etc.), decompensated cirrhosis, primary liver cancer;
- Underlying diseases of other vital organs (heart, kidney, lung, etc.) and bleeding disorders;
- Individuals lacking legal capacity or with poor insight.
Where it is running
- Shanghai East Hospital — Shanghai, Shanghai Municipality, China (enrolling)
Full record on ClinicalTrials.gov
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