A Study to Evaluate Efficacy and Safety of MK-8690 in Participants With Moderately to Severely Active Ulcerative Colitis (MK-8690-002)
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Colitis Ulcerative, Ulcerative Colitis
In brief
The purpose of this protocol is to evaluate the efficacy of MK-8690 in participants with moderately to severely active ulcerative colitis. The primary hypothesis is that MK-8690 is superior to placebo with respect to the proportion of participants achieving clinical remission per Modified Mayo Score at Week 12.
Key facts
- Study ID
- NCT07463183
- Run by
- Merck Sharp & Dohme LLC
- People needed
- 100
- Starts
- 2026-03-24
- Expected to finish
- 2028-12-21
- Last updated by the study team
- 2026-07-31
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Clinnova Research ( Site 1042) — Anaheim, California, United States (enrolling)
- Peak Gastroenterology Associates ( Site 1052) — Colorado Springs, Colorado, United States (enrolling)
- South Denver Gastroenterology, PC ( Site 1068) — Englewood, Colorado, United States (enrolling)
- Nature Coast Clinical Research ( Site 1045) — Inverness, Florida, United States (enrolling)
- Research Associates of South Florida - Miami - Southwest 8th Street ( Site 1072) — Miami, Florida, United States (enrolling)
- Gastroenterology Associates of Central Georgia ( Site 1060) — Macon, Georgia, United States (enrolling)
- University of Kansas Medical Center ( Site 1077) — Kansas City, Kansas, United States (enrolling)
- Tulane University School of Medicine ( Site 1073) — New Orleans, Louisiana, United States (enrolling)
- BVL Research - Kansas ( Site 1054) — Liberty, Missouri, United States (enrolling)
- Evangelismos General Hospital of Athens ( Site 1362) — Athens, Attica, Greece (enrolling)
- Radboudumc ( Site 1650) — Nijmegen, Gelderland, Netherlands (enrolling)
- EB Group Sp. Z o.o. Centrum Zdrowia MDM ( Site 1449) — Warsaw, Masovian Voivodeship, Poland (enrolling)
- Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś ( Site 1448) — Warsaw, Masovian Voivodeship, Poland (enrolling)
- Wonju Severance Christian Hospital ( Site 1602) — Wŏnju, Kang-won-do, South Korea (enrolling)
- Korea University Ansan Hospital ( Site 1603) — Ansan-si, Kyonggi-do, South Korea (enrolling)
- Kangbuk Samsung Hospital ( Site 1601) — Seoul, South Korea (enrolling)
- Huddersfield Royal Infirmary ( Site 1522) — Huddersfield, York, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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