Comparative Effects of Carnivore and Mediterranean-style Diets on LDL Aggregation and Cardiometabolic Health

Starting soon · Not applicable

Conditions studied: Atherosclerosis Cardiovascular Disease, Metabolic Syndrome, Dyslipidaemia

In brief

The goal of this clinical trial is to learn whether following a Mediterranean-style diet or a Carnivore-style diet can improve heart and metabolic health in men and women aged 30-60 years with high LDL cholesterol. The main questions it aims to answer are: 1. Does following a Mediterranean or Carnivore diet change how easily LDL cholesterol particles clump together (LDL aggregation susceptibility)? 2. Do these two diets have different effects on other measures of heart and metabolic health, such as blood fats, blood vessel function, and overall wellbeing? Researchers will compare people who follow the Mediterranean-style diet with those who follow the Carnivore-style diet to see which diet produces more beneficial changes in cholesterol and heart health markers. Participants will: * Attend three visits at Liverpool John Moores University for screening and data collection. * Be randomly assigned to follow either the Mediterranean or Carnivore diet for 3 weeks, matched for calories and protein. * Provide fasting blood, urine, and stool samples before and after the diet period. * Complete non-invasive cardiovascular tests to measure blood vessel and heart function. * Take part in a short interview and complete questionnaires about their experience of following the diet.

Key facts

Study ID

NCT07462871

Run by

Liverpool John Moores University

People needed

30

Starts

2026-06-01

Expected to finish

2027-06-01

Last updated by the study team

2026-03-13

Who can join

Age: 30 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female
• 30-60 years of age
• Elevated LDL cholesterol (LDL >3mmol/L and/or non-HDL cholesterol > 4mmol/L)
• Not following any specific diet for health reasons.
• Not currently taking lipid-lowering medications or supplements that may interfere with LDL levels.

You may not qualify if…

• Pregnancy or breastfeeding.
• Known food allergies or intolerances.
• Previous history of disordered eating.
• Currently taking cholesterol-lowering medication or supplements.

Where it is running

• Tom Reilly Building, Liverpool John Moores University — Liverpool, United Kingdom

Full record on ClinicalTrials.gov

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