Vagus Nerve-guided Laparoscopic Splenectomy and Azygoportal Disconnection

Recruiting now · Not applicable

Conditions studied: Cirrhosis, Hypersplenism, Hypertension, Portal

In brief

This study aimed to evaluate the effectiveness and safety of vagus nerve-guided laparoscopic splenectomy and azygoportal disconnection, and to assess its impact on postoperative digestive complications and quality of life.

Key facts

Study ID

NCT07462091

Run by

Northern Jiangsu People's Hospital

People needed

15

Starts

2026-03-25

Expected to finish

2027-03-31

Last updated by the study team

2026-04-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A clinical, radiological or histologic diagnosis of cirrhosis of any etiology
• Splenomegaly with secondary hypersplenism
• Bleeding portal hypertension
• No evidence of portal vein system thrombosis by ultrasound evaluation and angio-CT
• Informed consent to participate in the study

You may not qualify if…

• Delayed gastric emptying
• Diarrhea
• Hepatocellular carcinoma or any other malignancy,
• Hypercoagulable state other than the liver disease related
• DRUGS- oral contraceptives, anticoagulation or anti-platelet drugs.
• Child - Pugh C
• Recent peptic ulcer disease
• History of Hemorrhagic stroke
• Pregnancy.
• Uncontrolled Hypertension
• Human immunodeficiency virus (HIV) infection

Where it is running

• Clinical Medical College of Yangzhou University — Yangzhou, Jiangsu, China (enrolling)
• Clinical Medical College, Yangzhou University — Yangzhou, Jiangsu, China

Full record on ClinicalTrials.gov

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