Comparison of Two Vaginal Progesterone Forms in Frozen Embryo Transfer
Recruiting now
Conditions studied: Frozen Embryo Transfer (FET), Infertility, Artificial Cycle, Natural Cycle
In brief
The goal of this observational study is to compare two commonly used vaginal progesterone formulations - soft capsules versus pessaries - in women undergoing frozen embryo transfer (FET). The main question it aims to answer is: \- Do soft vaginal progesterone capsules provide similar or better patient satisfaction, convenience, and tolerability compared with vaginal progesterone pessaries during preparation for frozen embryo transfer? Participants undergoing FET who are prescribed vaginal progesterone as part of their endometrial preparation and luteal phase support will use one of the two formulations and complete patient-reported assessments regarding satisfaction, convenience, and tolerability. The study will also measure serum progesterone levels on the day of embryo transfer and evaluate pregnancy outcomes, including clinical pregnancy and live birth rates.
Key facts
- Study ID
- NCT07461909
- Run by
- Instituto Valenciano de Infertilidade de Lisboa
- People needed
- 400
- Starts
- 2024-11-08
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-03-10
Who can join
Age: 18 and older, up to 48. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age: ≥18 and <49 years old;
- Body Mass Index (BMI) ≥18.5 Kg/m2 and <30 Kg/m2;
- Planned for single blastocyst stage transfer;
- Has been prescribed two vaginal 200mg soft capsules or one 400mg pessary of progesterone, each 12hours before and after FET;
- Either AC-FET or NPP-FET.
You may not qualify if…
- Women who have previously enrolled in this study;
- Those unable to comprehend the investigational nature of the proposed study;
- Rank of FET>3;
- Use of oral/injectable corticoids.
Where it is running
- Instituto Valenciano de Infertilidade (IVI Lisboa) — Lisbon, Portugal (enrolling)
Full record on ClinicalTrials.gov
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