Efficacy of Apixaban in Treating Portal Vein Thrombosis Occurring More Than One Year After LSD
Recruiting now · Not applicable
Conditions studied: Cirrhosis, Splenectomy, Portal Vein Thrombosis, Hypertension, Portal
In brief
The purpose of this study is to determine whether Apixaban is effective and safe in the treatment of portal vein thrombosis Occurring more than one year after laparoscopic splenectomy and azygoportal disconnection.
Key facts
- Study ID
- NCT07461532
- Run by
- Northern Jiangsu People's Hospital
- People needed
- 20
- Starts
- 2026-04-01
- Expected to finish
- 2027-09-30
- Last updated by the study team
- 2026-03-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- A clinical, radiological, or histologic diagnosis of cirrhosis of any etiology.
- Portal hypertension bleeding .
- Splenomegaly with secondary hypersplenism.
- No evidence of portal vein thrombosis by ultrasound evaluation and angio-CT prior to surgery.
- Underwent laparoscopic splenectomy at our center.
- Orally received 2.5 mg of apixaban (CTTQ, Nanjing, China) twice daily or a 100 mg aspirin tablet (Bayer, Leverkusen, Germany) once daily for 6 months from POD 3.
- subcutaneous injections of low molecular weight heparin sodium (CSBio, Hebei, China) were administered for 5 days from POD 3
- Oral dipyridamole (Henan Furen, Henan, China) at a dosage of 25 mg, administered three times daily for 3 months from POD 3.
- Had no imaging evidence (Doppler ultrasound or CT) of portal vein thrombosis during postoperative months 6 to 12.
- Developed portal vein thrombosis after 12 months post-surgery.
- Provided informed consent to participate in the study.
You may not qualify if…
- Hepatocellular carcinoma or any other malignancy.
- Hypercoagulable state other than the liver disease related.
- DRUGS- oral contraceptives, anticoagulation or anti-platelet drugs.
- Child - Pugh C
- Recent peptic ulcer disease
- History of Hemorrhagic stroke
- Pregnancy.
- Uncontrolled Hypertension
- Human immunodeficiency virus (HIV) infection
Where it is running
- Clinical Medical College — Yangzhou, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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