Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy

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Conditions studied: Ankle Sprain, Ankle (Ligaments); Instability (Old Injury), Pain Management, ERAS, Ankle Arthroscopy

In brief

Ankle arthroscopy is increasingly performed as a day-case procedure, making rapid recovery and efficient discharge critical. Anesthetic technique substantially influences postoperative recovery, yet high-quality evidence comparing anesthetic strategies in ankle arthroscopy is limited. This multicenter randomized trial compares total intravenous anesthesia with propofol plus peripheral nerve block (PNB), general anesthesia plus PNB, and spinal anesthesia, with PACU-I recovery time as the primary outcome. Secondary outcomes include postoperative pain, opioid consumption, hospital length of stay, adverse events, recovery quality, satisfaction, limb weakness, and intraoperative hemodynamics.

Key facts

Study ID

NCT07460310

Run by

Second Affiliated Hospital, Zhejiang University, School of Medicine

People needed

200

Starts

2026-03-01

Expected to finish

2026-12-30

Last updated by the study team

2026-03-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Full understanding of the study procedures and methods, with a signed written informed consent form.
• Aged 18 to 65 years, of either sex.
• Scheduled for elective unilateral minimally invasive ankle surgery.
• American Society of Anesthesiologists (ASA) physical status classification I or II.
• Body Mass Index (BMI) between 16 and 32 kg/m\^2

You may not qualify if…

• Known hypersensitivity or allergy to any study medications or existing contraindications to anesthesia.
• Chronic obstructive pulmonary disease (COPD) or unstable asthma.
• History of difficult airway management, poorly controlled gastroesophageal reflux disease (GERD), or a known risk of aspiration.
• Anticipated surgical duration exceeding 3 hours.
• History of chronic preoperative opioid use or dependence.
• History of severe postoperative adverse reactions (e.g., severe postoperative nausea and vomiting).
• Pregnancy or lactation.
• History of seizure disorders or epilepsy.
• Severe peripheral neuropathy.
• Any other condition that, in the opinion of the investigator, would preclude safe participation in the study.

Full record on ClinicalTrials.gov

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