Comparison of Two Sedative Agents in Terms of Controlled Hypotension

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Conditions studied: Controlled Hypotension for Nasal Surgeries

In brief

Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention. So, it provides a better visiblity of surgical filed to the surgeons.This RCT compares propofol infusion vs isoflurane inhalation for inducing controlled hypotension during endoscopic sinus surgery. The goal is to assess which agent better controls blood pressure, improves surgical field visibility, and impacts recovery. It likely measures outcomes like hemodynamics, bleeding, and surgeon satisfaction.

Key facts

Study ID

NCT07460050

Run by

Hayatabad Medical Complex

People needed

136

Starts

2026-03-01

Expected to finish

2026-08-01

Last updated by the study team

2026-03-10

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Either male/female Age 18-65 Patients undergoing endoscopic sinus surgery as per the operational definition

You may not qualify if…

• Patients with cardiovascular disease Patients with pregnancy Patients with coagulopathy Patients on beta blockers or calcium channel blockers

Where it is running

• Hayatabad Medical Complex, Peshawar — Peshawar, Khyber Pakhtunkhwa, Pakistan

Full record on ClinicalTrials.gov

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