"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"

Recruiting now · Phase 4

Conditions studied: Periodontitis

In brief

The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy. The main question it aims to answer is: "Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?"

Key facts

Study ID

NCT07459049

Run by

University of Baghdad

People needed

30

Starts

2025-12-01

Expected to finish

2026-08-01

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• systemically healthy patients.
• having a minimum of 20 teeth.
• Generalized unstable periodontitis.
• Pocket depth [≥ 4 mm].
• All included participants should be adults aged more than 18 years .
• smokers and non smokers

You may not qualify if…

• Allergy or hypersensitivity to Ibuprofen or other NSAIDs.
• current systemic anti-inflammatory or antibiotic therapy (<3 months).
• peptic ulcer disease.
• recent periodontal therapy (<3 months).
• Asthma.
• Renal impairment .
• Hepatic impairment.
• Severe cardiac disease (heart failure, hypertension (.
• Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants .
• Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections.
• pregnant or lactating females.
• those being unable to provide written informed consent.

Where it is running

• College of Dentistry, University of Baghdad — Baghdad, Iraq (enrolling)

Full record on ClinicalTrials.gov

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