International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes

Starting soon

Conditions studied: Large Bowel Obstruction

In brief

Mechanical large-bowel obstruction is a common and high-risk emergency surgical condition with substantial variation in diagnostic evaluation, operative timing, and management strategies across institutions and healthcare systems. Evidence guiding optimal management remains limited and is largely derived from retrospective or single-center studies. IMPEL is an international, multicenter, time-bound, prospective observational cohort study designed to characterize real-world presentation, diagnostic pathways, operative and non-operative management, and short-term outcomes in adults presenting with mechanical large-bowel obstruction. By capturing standardized patient-level, radiologic, operative, and outcome data across diverse acute care settings, IMPEL aims to describe contemporary practice patterns, quantify variation in care, and identify factors associated with morbidity, mortality, and stoma-related outcomes.

Key facts

Study ID

NCT07458867

Run by

European Society for Trauma and Emergency Surgery

People needed

500

Starts

2026-07-01

Expected to finish

2027-07-31

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Hospital admission with mechanical large-bowel obstruction, with or without associated perforation
• Managed operatively or non-operatively according to local standard practice

You may not qualify if…

• Functional or pseudo-obstruction without a mechanical lesion
• Pediatric patients (<18 years)
• Patients not admitted to hospital
• Isolated large-bowel perforation unrelated to obstruction

Full record on ClinicalTrials.gov

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