Vitamin D for Acute Intracerebral Hemorrhage

Recruiting now · Not applicable

Conditions studied: Intracerebral Hemorrhage

In brief

Intracerebral hemorrhage (ICH) is the most deadly and debilitating form of stroke. To date, effective treatment that could improve the functional outcome of ICH remained elusive. In a mice model of ICH, it was demonstrated that high dose Vitamin D (VitD) treatment enhanced hematoma resolution by promoting reparative macrophage differentiation and improved neurobehavioral performance in mice. Hence, this pilot study aimed to investigate the feasibility and safety of VitD treatment for ICH in human subjects. VICToHR is a prospective, randomized, open-label, blinded-endpoint (PROBE) trial. Participants will be randomized 1:1 to receive either VitD or standard care (control). The intervention group will receive VitD 4000 IU daily for 2 weeks, followed by 1000 IU daily for 24 weeks. The primary outcomes are the rate of hematoma resolution at 14 days and the incidence of hypercalcemia and VitD toxicity. Hematoma volume will be assessed by a neuroradiologist who is blinded to treatment allocation.

Key facts

Study ID

NCT07458815

Run by

The University of Hong Kong

People needed

40

Starts

2026-03-01

Expected to finish

2028-02-28

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Spontaneous ICH diagnosis
• Age ≥ 18 years
• Within 96 hours of ICH
• Premorbid Modified Rankin Scale of ≤2
• Supratentorial ICH
• ICH volume ≥2 mL

You may not qualify if…

• Expected life expectancy of <1 year
• Glasgow Coma Scale <9
• Anticipated surgical evacuation of hematoma
• Inability to participate in follow-up activity
• Hypercalcemia
• Hyperphosphatemia
• History of kidney stones
• Bleeding tendency
• Severe renal impairment
• Severe liver impairment
• Known contraindication or allergy to vitamin D

Where it is running

• The University of Hong Kong — Hong Kong, Hong Kong (enrolling)

Full record on ClinicalTrials.gov

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