Healthy Expectancy Through Routine Antenatal STI Screening
Recruiting now · Not applicable
Conditions studied: Antenatal Health, Antenatal Care, STI, Chlamydia Trachomatis Infection in Pregnancy, Chlamydia, Chlamydia Trachomatis, Chlamydia Trachomatis Infection, Preterm Birth
In brief
This study will evaluate whether routine screening and treatment for two common sexually transmitted infections, chlamydia and gonorrhoea, during pregnancy can reduce preterm birth and other poor birth outcomes in Botswana, and whether this approach is affordable and cost-effective for the health system. About 2,000 pregnant women attending their first antenatal care visit at up to 10 government clinics in Botswana will be invited to join the study. All women will first receive the usual antenatal care services provided in Botswana, including routine health checks and HIV and syphilis testing. Women who enroll in the study will be randomly assigned to one of two groups: 1. Standard of care group: Women receive routine antenatal care only. 2. Intervention group: In addition to routine antenatal care, women are screened for chlamydia and gonorrhoea using self-collected vaginal swabs at their first antenatal care visit and again in the third trimester. The main outcome of the study is whether screening and treating chlamydia and gonorrhoeae reduces preterm birth (before 37 weeks). Other outcomes include low birth weight, very preterm birth, and maternal health conditions.
Key facts
- Study ID
- NCT07458802
- Run by
- Adriane Wynn
- People needed
- 2000
- Starts
- 2026-05-25
- Expected to finish
- 2030-07-01
- Last updated by the study team
- 2026-07-02
Who can join
Age: 15 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Asymptomatic for cervicovaginitis at first ANC (i.e., not syndromically treated for an STI by clinic midwives at first ANC)
- Age ≥ 15 years
- Currently pregnant
- ≤20 weeks gestation (based on gestational age in obstetric record or last menstrual period if gestational age missing from record)
- Attending first ANC visit
- Residence in Gaborone, Bostwana or surrounding villages through the time of delivery
- Mentally competent to understand study procedures or give informed consent
Where it is running
- Botswana Harvard Health Partnership — Gaborone, Botswana (enrolling)
Full record on ClinicalTrials.gov
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