Evaluation of [18F]GATT-44 for Positron Emission Tomography Imaging of the GABA Transporter-1
Recruiting now · Early Phase 1
Conditions studied: Healthy Adult Participants
In brief
Evaluate \[18F\]GATT-44 (aka \[18F\]GAT44), to characterize its pharmacokinetic, metabolic, and in vivo binding profile, and assess the reproducibility of kinetic and binding parameters. Assess specific binding levels of \[18F\]GATT-44 by conducting a test-block study in humans. Estimate human dosimetry of \[18F\]GATT-44 by performing whole-body imaging studies.
Key facts
- Study ID
- NCT07457736
- Run by
- Yale University
- People needed
- 32
- Starts
- 2026-04-01
- Expected to finish
- 2030-01-01
- Last updated by the study team
- 2026-04-06
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Willing and able to give voluntary written informed consent;
- Able to read and write, able to communicate effectively with the investigator, and comply with all study requirements, restrictions, and directions of the research staff;
- Male or female, aged 18 to 60, at screening;
- In good general health as evidenced by medical history, physical examination, ECG, serum/urine biochemistry, hematology, and serology tests;
- Females of childbearing potential, and male subjects, must be willing to practice birth control for the duration of the study (unless medical documentation is provided confirming subject is permanently sterile).
- Exclusion:
- Less than 18 years of age;
- Pregnant or breastfeeding;
- Any significant systemic illness or unstable medical condition;
- Pre-existing medical conditions or claustrophobic reactions;
- Research-related radiation exposure exceeds current PET Center guidelines;
- History of a bleeding disorder or are currently taking anticoagulants.
Where it is running
- Yale University PET Center — New Haven, Connecticut, United States (enrolling)
Full record on ClinicalTrials.gov
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