Collagen Peptides and Cellular Aging

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Longevity, Healthy Aging, Biological Ageing

In brief

The goal of this clinical trial is to learn if daily collagen peptide supplementation can stabilize or lengthen telomeres and improve related markers of cellular aging in adults aged 50-70 years with overweight and low-to-moderate physical activity (healthy volunteers without major chronic disease). Main questions it aims to answer are: Does six months of collagen peptides stabilize or extend telomere length and increase telomerase activity compared with placebo? Are any telomere-related changes associated with lower inflammation, healthier body composition, and better functional health? Researchers will compare collagen as an intervention to a placebo group to see if collagen will influence aging markers. Participants will take collagen peptides or a placebo daily for 24 weeks. They will attend three study visits: one before starting the intervention (T0), one at 3 months (T1), and one at 6 months (T2). At each visit, blood samples will be collected to measure telomere length, telomerase activity, and inflammation/redox markers. Participants will also undergo body composition assessments using bioelectrical impedance, complete functional tests of muscle strength and mobility, and fill out questionnaires on health and vitality.

Key facts

Study ID

NCT07456449

Run by

University of Vienna

People needed

125

Starts

2026-04-22

Expected to finish

2028-08-01

Last updated by the study team

2026-05-05

Who can join

Age: 50 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 50-70 years; both male and female participants are eligible
• Body mass index (BMI) 25-30 kg/m²
• Low to moderate physical activity: not meeting current WHO recommendations (<150 minutes/week) or ≤2 sessions/week structured training
• Able to live independently and mobile in daily life
• No regular resistance training within the past 6 months
• Provision of written informed consent

You may not qualify if…

• Diagnosed chronic diseases relevant to the immune system, metabolism, or cellular aging (e.g., diabetes mellitus, cancer, cardiovascular, rheumatologic diseases)
• Use of immunomodulatory, systemic anti-inflammatory, or hormonal medications (e.g., corticosteroids, immunosuppressants)
• Acute infections or surgeries within the last 3 months
• Regular use of supplements known to affect oxidative stress or cellular aging (e.g., high-dose antioxidants, CoQ10, omega-3 fatty acids, high-dose vitamin D)
• Participation in another clinical study within the last 3 months
• Vegetarian or vegan diet (product contains animal-derived collagen)

Where it is running

• University of Vienna, NuTraLab — Vienna, State of Vienna, Austria (enrolling)

Full record on ClinicalTrials.gov

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