Auditory Processing in DOC Patients
Starting soon
Conditions studied: Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
In brief
This prospective observational study investigates whether electroencephalography (EEG) can improve the differentiation between unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS) in patients with severe acquired brain injury. The study further examines the association between EEG markers of auditory processing and long-term functional outcome at 12 months.
Key facts
- Study ID
- NCT07455682
- Run by
- BDH-Klinik Hessisch Oldendorf
- People needed
- 42
- Starts
- 2026-04-15
- Expected to finish
- 2028-03-31
- Last updated by the study team
- 2026-03-06
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Presence of a disorder of consciousness (Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State [MCS]), classified using the Coma Recovery Scale-Revised (CRS-R) based on three assessments conducted on at least two separate days
- Age between 18 and 80 years
- Written informed consent provided by the patient's legal representative
- Preserved brainstem auditory evoked potentials (BAEPs) on at least one side
You may not qualify if…
- Ongoing sedation at the time of EEG assessment
- Current treatment with medications known to significantly affect cortical functional state, including barbiturates, neuroleptics (antipsychotics), antiepileptic drugs, benzodiazepines, or comparable agents
- Colonization with multidrug-resistant organisms requiring isolation precautions (e.g., 4MRGN)
- Pregnancy
- Impaired language comprehension (e.g., insufficient German language proficiency or aphasia)
- Temporal bone fractures or severe infratentorial brain injury associated with unilateral or bilateral absence of auditory evoked potentials (AEPs)
- Bilateral hearing impairment or deafness, or presence of a cochlear implant
- Scalp wounds or conditions preventing placement of an EEG electrode cap
Where it is running
- BDH-Klinik Hessisch Oldendorf — Hessisch Oldendorf, Lower Saxony, Germany
Full record on ClinicalTrials.gov
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