Study of S-4321 in Participants With an Autoimmune or Immune-mediated Disease

Recruiting now · Phase 1

Conditions studied: Autoimmune Diseases, Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Psoriasis (PsO), Cutaneous Lupus Erythematosus (CLE), Atopic Dermatitis (AD)

In brief

This is a multi-center, open-label Ph 1b basket study to assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, biomarker response, and preliminary efficacy of multiple doses of S-4321 in adults with autoimmune or immune-mediated disease including rheumatoid arthritis (RA), psoriatic arthritis (PsA), psoriasis (PsO), cutaneous lupus erythematosus (CLE) with or without systemic manifestations, or atopic dermatitis (AD).

Key facts

Study ID
NCT07455578
Run by
Seismic Therapeutic AU Pty Ltd
People needed
24
Starts
2026-06-01
Expected to finish
2027-09-01
Last updated by the study team
2026-06-01

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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