Observational Clinical Study on the Association Between Lactate-mediated Gut Microbiota Alterations and Disease Progression in Liver Cirrhosis.

Starting soon

Conditions studied: Cirrhosis

In brief

To investigate the association between lactate-mediated alterations in the gut microbiota and disease progression in patients with liver cirrhosis; and to examine the correlations of lactate levels among serum, fecal, and tissue samples in patients with liver cirrhosis.

Key facts

Study ID

NCT07455175

Run by

Zhujiang Hospital

People needed

200

Starts

2026-04-01

Expected to finish

2028-10-01

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 1. Healthy individuals without a history of liver disease or related underlying disorders; or patients diagnosed with liver cirrhosis and its complications based on imaging and/or liver biopsy, with a history of chronic liver disease for more than 6 months. Etiologies include chronic hepatitis B virus infection, nonalcoholic fatty liver disease, and alcoholic liver disease, among others.
• Willing to participate in this study and able to provide written informed consent.

You may not qualify if…

• 1. A history of severe organic diseases involving the liver, gastrointestinal tract, kidneys, or other organ systems; malignant tumors; or autoimmune diseases.
• Patients with acute infection or inflammatory diseases within the past 1 month.
• Pregnant or breastfeeding women.

Where it is running

• Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong, China

Full record on ClinicalTrials.gov

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