e-ALIGN: A Patient Portal-based Intervention to Align Medications With What Matters Most
Recruiting now · Not applicable
Conditions studied: Dementia, Potentially Inappropriate Medication Use, Mild Cognitive Impairment (MCI)
In brief
The overarching goal of this study is to pilot an intervention in which older adults with mild cognitive impairment and dementia and the older adult's care partners are identified in primary care and provided with educational materials through the patient portal to engage the participant in deprescribing. The multicomponent intervention, e-Align, includes delivery of educational information through the patient portal, and a pharmacist-led intervention to align medications with patient and care partner goals and reduce use of central nervous system (CNS) potentially inappropriate medicines (PIM). This work will establish the preliminary data, methods, and partnerships to undertake a multisite embedded pragmatic clinical trial. The resulting triadic-based behavioral intervention will promote patient and care partner engagement, and foster care that aligns with patients' values, and promote improved health and well-being outcomes for people with cognitive impairment and the patient's care partners through deprescribing.
Key facts
- Study ID
- NCT07454824
- Run by
- Johns Hopkins University
- People needed
- 100
- Starts
- 2026-04-15
- Expected to finish
- 2027-02-06
- Last updated by the study team
- 2026-06-16
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients: Age ≥65, with a diagnosis of MCI or dementia based on ICD-10 codes and ≥1 active CNS-PIM, who are active patient portal users.
- Care partners:
- Family or other companions >21 years who regularly help the patient with managing medications.
You may not qualify if…
- As the trial will be based in primary care, individuals residing in long term care facilities or enrolled in hospice will be excluded.
Where it is running
- Johns Hopkins Community Physicians — Baltimore, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
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