Mechanisms of Atrial Pathoelectrophysiology in HCM

Starting soon

Conditions studied: Hypertrophic Cardiomyopathy (HCM), Atrial Fibrillation (AF)

In brief

This study aims to learn why atrial fibrillation (AF), a type of irregular heartbeat, happens more often and is harder to treat in people with hypertrophic cardiomyopathy (HCM). HCM is an inherited condition where the heart muscle is thicker than usual. Researchers will study electrical signals from the heart and advanced heart imaging. By doing this, they hope to better understand how AF behaves in people with HCM and why treatments may not work as well for them. The information from this study may help improve future treatments for people who have both HCM and AF.

Key facts

Study ID

NCT07454135

Run by

Guy's and St Thomas' NHS Foundation Trust

People needed

40

Starts

2026-03-08

Expected to finish

2027-09-30

Last updated by the study team

2026-04-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Paroxysmal or persistent atrial fibrillation
• Diagnosis of hypertrophic cardiomyopathy
• Patient planning to proceed to atrial fibrillation ablation following clinical consultation
• Age 18-80 years
• Able and willing to provide written informed consent
• Able and willing to comply with study follow up requirements

You may not qualify if…

• Any clinical contra-indication to ablation
• Any disease limiting life expectancy to <1 year
• Potential participant currently pregnant or breast feeding
• Contraindication to MRI including renal dysfunction (eGFR<30ml/min)
• Unable to understand verbal or written explanations given in English

Where it is running

• Guy's and St Thomas' NHS Foundation Trust — London, United Kingdom

Full record on ClinicalTrials.gov

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