Comparison of Topical Calcipotriol and Intralesional Steroids in Alopecia Areata
Starting soon · Phase 4
Conditions studied: Alopecia Areata
In brief
This randomized controlled trial compares the effectiveness of topical calcipotriol and intralesional corticosteroids in the treatment of alopecia areata. Alopecia areata is an autoimmune condition that causes non-scarring hair loss and can significantly affect quality of life. Intralesional corticosteroids are commonly used as first-line therapy; however, response rates vary and treatment may be associated with discomfort and local adverse effects. Sixty adult patients with patchy alopecia areata involving less than 50% of the scalp were randomly assigned to receive either topical calcipotriol or intralesional corticosteroid injections for 12 weeks. Participants were evaluated at four-week intervals. Treatment response was assessed using the Severity of Alopecia Tool (SALT) score and percentage improvement from baseline. The primary objective is to compare reduction in SALT score between the two treatment groups. Secondary outcomes include overall treatment efficacy and safety. The findings aim to determine whether topical calcipotriol provides superior or comparable clinical benefit to intralesional corticosteroids in patients with alopecia areata.
Key facts
- Study ID
- NCT07453238
- Run by
- Hayat Abad Medical Complex, Peshawar
- People needed
- 60
- Starts
- 2026-04-01
- Expected to finish
- 2026-10-01
- Last updated by the study team
- 2026-03-05
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18 to 50 years
- Clinically diagnosed patchy alopecia areata
- Scalp involvement of less than 50% (SALT score <50%)
- No topical or systemic treatment for alopecia areata within the previous 3 months
- Willingness to provide written informed consent
You may not qualify if…
- Diffuse alopecia areata or scarring alopecia
- Presence of other autoimmune diseases or significant systemic illness
- Known hypersensitivity to calcipotriol or corticosteroids
- Pregnant or lactating women
- Current use of immunosuppressive therapy
- Unwillingness to participate or provide informed consent
Full record on ClinicalTrials.gov
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