Comparing Two Root Canal Cleaning Solutions (Chlorhexidine vs. Sodium Hypochlorite) for Pain After Treatment
Starting soon · Not applicable
Conditions studied: Postoperative Pain
In brief
Brief Summary (A short description for the lay public) This study aims to find out if the type of cleaning solution used during a root canal affects the pain a patient feels the next day. A root canal procedure involves cleaning the inside of the tooth. Two common cleaning solutions are chlorhexidine (CHX) and sodium hypochlorite (NaOCl, also known as bleach). While both are effective, it is not clear if one causes more discomfort than the other. In this research, half of the participants will have their root canal cleaned with CHX, and the other half with NaOCl. We will then ask all participants to rate their pain 24 hours after the procedure using a simple pain scale. Our goal is to see if there is a difference in pain levels between the two groups. The results will help dentists choose the best solution to make their patients more comfortable after treatment
Key facts
- Study ID
- NCT07453160
- Run by
- College of Physicians and Surgeons Pakistan
- People needed
- 90
- Starts
- 2026-02-15
- Expected to finish
- 2026-06-15
- Last updated by the study team
- 2026-03-05
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 18-65 years
- Any gender
- Requiring non-surgical root canal treatment
- Willing to provide written informed consent
- Able to report postoperative pain using a validated pain assessment scale -
- Exclusion Criteria:Known hypersensitivity or allergy to chlorhexidine or sodium hypochlorite
- Systemic conditions affecting pain perception (e.g., diabetes with neuropathy, fibromyalgia)
- Medications affecting pain perception (e.g., chronic analgesics, corticosteroids, antidepressants)
- Preoperative dental pain in the tooth scheduled for treatment
- Pregnancy or lactation
- Teeth with resorbed roots
- Mobile teeth (pathological mobility)
- Open apices
Full record on ClinicalTrials.gov
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