Predicting Vital Pulp Treatment Outcomes in Symptomatic Pulpits Using Metabolic Biomarker
Recruiting now · Not applicable
Conditions studied: Pulp Disease, Dental, Pulpitis, Reversible Pulpitis, Irreversible Pulpitis (Toothache)
In brief
This prospective controlled clinical trial investigates whether metabolic biomarkers measured in pulpal blood at the time of carious pulp exposure can predict the 12-month outcomes of vital pulp treatment in symptomatic permanent teeth. Eligible patients aged 16-50 years presenting with deep carious pulp exposure will undergo vital pulp therapy (partial pulpotomy or full pulpotomy). Pulpal blood samples will be collected at the time of exposure and analyzed using High-Performance Liquid Chromatography (HPLC). Treatment outcomes will be assessed clinically and radiographically at 12 months. The study aims to identify objective, measurable biomarkers that can improve pulpal diagnosis and guide clinical decision-making in vital pulp therapy.
Key facts
- Study ID
- NCT07452614
- Run by
- Abeer Ghalib Abdul-khaliq
- People needed
- 60
- Starts
- 2026-02-20
- Expected to finish
- 2028-10-01
- Last updated by the study team
- 2026-04-01
Who can join
Age: 16 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age range of 16-50 years.
- Pulp exposure during treatment of deep caries.
- Absence of periodontitis or systemic disease.
- Only one or two proximal surfaces lost with remaining walls > 2 mm; and
- Good compliance and signed informed consent forms.
You may not qualify if…
- Patients who meet any of the following criteria will be excluded:
- Teeth with unrestorable large defects or the need for RCT for aesthetic reasons;
- Teeth with a negative response to cold testing
- Current pregnancy or breastfeeding;
- Poor compliance or inability to complete the trial.
- The use of medications, including antibiotics, bisphosphonates, or statins, within 3 weeks before the study.
- Inadequate blood sample collection after pulpal exposure.
Where it is running
- College of dentistry\ University of Baghdad — Baghdad, Iraq (enrolling)
Full record on ClinicalTrials.gov
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