What is the Role of Type III/IV Muscle Afferents in Airway Resistance and Thermoregulatory Responses to Exercise?
Starting soon · Early Phase 1 · Has a placebo group
Conditions studied: Placebo - Control, Experimental
In brief
Exercise places serious demands on the body. These demands are fundamentally caused by increases in oxygen demand and the consequent increase in body temperature. These demands are met by several physiological responses, including increases in heart rate, blood pressure, breathing and blood flow. These responses must be proportional to the increase in demand and some signal must relay information from the muscle to the brain. Group III/IV afferents do just this. They relay information about the muscle (movement, temperature, acidity, etc.) up to the brain so that appropriate responses are mounted. There is strong evidence in animals that group III/IV afferents play a key role in making breathing easier (decreasing airway resistance) and initiating sweating and blood flow responses. There has been no research on the role of group III/IV afferents on these fundamental exercise responses in humans. The investigators propose to isolate the role of group III/IV afferents on regulate airway resistance, sweating and blood flow responses to exercise in humans.
Key facts
- Study ID
- NCT07452094
- Run by
- Northern Arizona University
- People needed
- 15
- Starts
- 2026-04-01
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2026-03-05
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- regularly physically active as determined via questionnaires (Par-Q \& You)
- maximal aerobic power 30 mL/min/kg (female), 40 mL/kg/min (male)
You may not qualify if…
- current smokers
- acute bronchial asthma
- diabetics
- chronic back pain
- peripheral neuropathy
- chronic obstructive airway or status asthmaticus
- obese (body mass index > 30 kg/m2)
- convulsive disorders
- requiring daily medications that may affect responses to exercise (e.g. anti-hypertensive, anti-arrhythmogenics, blood thinners)
- history of drug abuse
- history of disease/dysfunction that could cause complication with exercise (e.g. cardiovascular, respiratory, neurological, musculoskeletal)
- irregular or absent menstrual cycle
- pregnant or suspected pregnancy
- adverse response to physical exercise
- current or history of esophageal or gastric disease, or frequent heart burn (>2x per week)
- Lidocaine allergy
Where it is running
- Northern Arizona University — Flagstaff, Arizona, United States
Full record on ClinicalTrials.gov
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