Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease

Recruiting now · Phase 1/Phase 2

Conditions studied: Huntington Disease

In brief

The purpose of this research study is to determine whether an implantation of hNSC-01 is a safe and tolerable study intervention for Huntington's disease. This study is the first time that hNSC-01 is being tested in people.

Key facts

Study ID

NCT07451613

Run by

Leslie Thompson

People needed

21

Starts

2026-04-06

Expected to finish

2031-01-01

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have decision-making capacity and be able to provide written informed consent.
• Are between 18 to 65 years of age
• Have genetically confirmed diagnosis of Huntington's Disease
• Able to undergo MRI scans, tolerate neurosurgical procedure, blood draws and lumbar puncture.

You may not qualify if…

• Are pregnant
• Test positive for human immunodeficiency virus (HIV), hepatitis C or chronic hepatitis B at Screening
• Have an implanted deep brain stimulation device.

Where it is running

• University of California, Irvine — Irvine, California, United States (enrolling)

Full record on ClinicalTrials.gov

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