PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)

Recruiting now · Not applicable

Conditions studied: Ageing

In brief

As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens. Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based on patient response. This approach integrates lifestyle modifications, dietary supplements, and pharmacological agents to optimize physical, cognitive, and immune function across the lifespan .

Key facts

Study ID

NCT07451496

Run by

National University of Singapore

People needed

20

Starts

2025-09-29

Expected to finish

2026-06-30

Last updated by the study team

2026-03-05

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 50-80 years (both male and female)
• Relatively healthy and in stable health condition
• Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained)
• VO₂peak below the 75th percentile for age- and sex-specific norms
• Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery
• Willing and able to comply with exercise and supplementation protocols
• English-literate (can read and understand English)
• Provides written informed consent
• Deemed to have mental capacity, as assessed by the Principal Investigator
• Are able to attend all research visits for screening and research data collection at MD11, Yong Loo Lin School of Medicine, National University of Singapore

You may not qualify if…

• Significant change in medication in the past 3 months
• History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke)
• More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD)
• Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients
• Participation in another interventional clinical trial
• Current use of any study-related supplement unless willing to stop
• Any medical, psychiatric, or cognitive condition deemed by the PI to jeopardise safety or compliance
• Pregnant or planning pregnancy during the study period
• Any conditions deemed by PI that jeopardize the safety or study compliance

Where it is running

• MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore 117597 — Singapore, Singapore, Singapore (enrolling)

Full record on ClinicalTrials.gov

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