Field Study on Intravenous Iloprost for Treatment of Severe Frostbite at High Altitude

Starting soon

Conditions studied: Frostbite, Altitude, Field Physician Care

In brief

The goal of this observational study is to learn whether intravenous iloprost treatment for severe frostbite (grades 3-4) is feasible and safe when delivered in pre-hospital, remote high-altitude settings. The main questions it aims to answer are: * Is it feasible to initiate and deliver guideline-based intravenous iloprost for grade 3-4 frostbite at high altitude and what logistical barriers arise? * Does field-based initiation of iloprost increase tissue preservation and reduce amputations (compared to historical cases from similar settings)? Participants receiving Iloprost as part of a frostbite treatment will be followed up after discharge as well as 6, 12 and 18 months to assess tissue preservation and long-term sequelae from the initial frostbite injury.

Key facts

Study ID

NCT07450469

Run by

Institute of Mountain Emergency Medicine

People needed

10

Starts

2026-05-01

Expected to finish

2028-05-01

Last updated by the study team

2026-03-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Frostbite grade 3/4 eligible for Iloprost
• <72h of thawing
• min. age of 18 years
• provision of written informed consent

You may not qualify if…

• age <18 years
• general contraindication
• pregnancy
• inability/denial to provide informed consent

Where it is running

• Eurac Research, Institute of Mountain Emergency Medicine — Bolzano, BZ, Italy

Full record on ClinicalTrials.gov

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