CAPRI: A Phase 3 Randomized, Double-Masked Study Comparing the Efficacy of EYP-1901 Against Aflibercept in DME

Recruiting now · Phase 3

Conditions studied: Diabetic Macular Edema, DME, Diabetic Macular Edema (DME)

In brief

This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.

Key facts

Study ID

NCT07449923

Run by

EyePoint Pharmaceuticals, Inc.

People needed

240

Starts

2026-02-09

Expected to finish

2028-10-01

Last updated by the study team

2026-08-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Previously treated or treatment naïve patients with a documented diagnosis of macular edema associated with diabetic retinopathy (DR) in the study eye, with onset of disease that began at any time prior to the Screening Visit.
• Best-corrected visual acuity (BCVA) Early Treatment Diabetic Retinopathy Study (ETDRS) letter score of 35 letters (20/200 Snellen equivalent) to 78 letters (20/32 Snellen equivalent) in the study eye at the Screening Visit and at Baseline (Day 1).
• For previously treated participants: at least 1 injection of anti-VEGF in the past 12 months, the most recent anti-VEGF treatment for DME must not have been administered less than 12 weeks prior to the Screening Visit.

You may not qualify if…

• BCVA using ETDRS charts <30 letters (20/250 Snellen equivalent) in the fellow eye.

Where it is running

• Associated Retina Consultants - Phoenix — Phoenix, Arizona, United States (enrolling)
• Phoenix Retina Clinical Trials, LLC - North Phoenix — Phoenix, Arizona, United States (enrolling)
• Retina Macula Institute of Arizona — Scottsdale, Arizona, United States (enrolling)
• Retina Vitreous Associates Medical Group — Beverly Hills, California, United States (enrolling)
• Retina Consultants of Orange County — Fullerton, California, United States (enrolling)
• South Coast Retina Center — Long Beach, California, United States (enrolling)
• Retinal Consultants Medical Group - Modesto — Modesto, California, United States (enrolling)
• Kaiser Permanente — Oakland, California, United States (enrolling)
• Retina Consultants of Southern California — Redlands, California, United States (enrolling)
• Bay Area Retina Associates — Walnut Creek, California, United States (enrolling)
• Retina Specialists of Colorado - Arvada — Arvada, Colorado, United States (enrolling)
• Connecticut Eye Consultants, P.C. — Danbury, Connecticut, United States (enrolling)
• Coastal Eye Surgeons, LLC — Greenwich, Connecticut, United States (enrolling)
• Retina Group of New England, PC — Waterford, Connecticut, United States (enrolling)
• Retina Group of Florida - Fort Lauderdale — Fort Lauderdale, Florida, United States (enrolling)
• Retina Specialty Institute — Pensacola, Florida, United States (enrolling)
• Fort Lauderdale Eye Institute — Plantation, Florida, United States (enrolling)
• MedEye Associates — South Miami, Florida, United States (enrolling)
• Retina Vitreous Associates of Florida - Saint Petersburg — St. Petersburg, Florida, United States (enrolling)
• Retina Vitreous Associates of Florida — Tampa, Florida, United States (enrolling)
• Retina Associates — Elmhurst, Illinois, United States (enrolling)
• University Retina and Macula Associates — Lemont, Illinois, United States (enrolling)
• Illinois Retina Associates, S.C. — Oak Park, Illinois, United States (enrolling)
• Associated Vitreoretinal & Uveitis Consultants - Carmel — Carmel, Indiana, United States (enrolling)
• Associated Retina Consultans — Gilbert, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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