SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Knee Osteoarthritis

In brief

This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under spinal anesthesia. SII, calculated as platelet × neutrophil / lymphocyte count, is used as a composite marker of perioperative inflammatory and immune response. The study investigates whether iPACK block with ACB attenuates the systemic inflammatory reaction to surgical trauma compared to sham block.

Key facts

Study ID

NCT07449442

Run by

Poznan University of Medical Sciences

People needed

60

Starts

2026-03-01

Expected to finish

2026-06-30

Last updated by the study team

2026-05-22

Who can join

Age: 65 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with ASA classification I-III
• Aged 65-100 years
• Who will be scheduled for hip arthroplasty under spinal anesthesia

You may not qualify if…

• Patients who have a history of bleeding diathesis
• Take anticoagulant therapy
• History of chronic pain before surgery
• Multiple trauma
• patients unable to assess their pain (dementia)
• patients operated under general anesthesia
• patients having an infection in the region of the procedure
• the patient who does not accept the procedure

Where it is running

• Poznan University of Medical Sciences — Poznan, Poland (enrolling)

Full record on ClinicalTrials.gov

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