Registry Study of People Who Are Having an Esophagectomy and Are at High Risk of Anastomotic Leak

Recruiting now

Conditions studied: Esophageal Malignant Neoplasm Primary, Anastomotic Leak

In brief

The main purpose of this study is to look at how often anastomotic leaks happen in participants who are at high risk of these leaks and are eligible to receive gastric preconditioning by percutaneous angioembolization before an esophagectomy.

Key facts

Study ID

NCT07449208

Run by

Memorial Sloan Kettering Cancer Center

People needed

40

Starts

2026-02-25

Expected to finish

2029-02-25

Last updated by the study team

2026-03-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Documentation of Disease
• Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy.
• Patients must also have risk factors for anastomotic leak:
• Previous foregut or bariatric surgery (gastric sleeve or gastric bypass), but excluding fundoplication-only surgery OR
• Salvage esophagectomy OR
• Planned cervical anastomosis OR
• Two or more comorbidities:
• Diabetes, obesity, coronary artery disease, vascular disease (including celiac stricture or atherosclerosis, significant aortic disease, or any previous diagnosis of peripheral arterial disease), steroid use, hypertension, current or former smoker, renal insufficiency, and heart failure.
• Definition of Disease
• Patients must have pathologically confirmed esophageal malignancy requiring esophagectomy and risk factors for anastomotic leak, as described above.
• Patients must be candidate and have agreed to receive gastric preconditioning procedure
• Prior Treatment
• o There are no requirements with regard to prior treatment.
• Age ≥ 18
• ECOG Performance Status of ≤ 2 (See Appendix I for performance status criteria)

Where it is running

• Memorial Sloan Kettering Basking Ridge (All Protocol Activities) — Basking Ridge, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Monmouth (All Protocol Activities) — Middletown, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Bergen (All Protocol Activities) — Montvale, New Jersey, United States (enrolling)
• Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities) — Commack, New York, United States (enrolling)
• Memorial Sloan Kettering Westchester (All protocol activities) — Harrison, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Nassau (All Protocol Activities) — Rockville Centre, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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