Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment

In brief

The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.

Key facts

Study ID

NCT07449117

Run by

Masaryk University

People needed

70

Starts

2026-03-01

Expected to finish

2028-12-01

Last updated by the study team

2026-03-04

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI).

You may not qualify if…

• Any severe psychiatric disorder.
• History of other neurological diseases affecting the central nervous system.
• Severe head trauma.
• Uncompensated internal or oncological disease.
• Presence of MRI-incompatible metal in the body (e.g., pacemaker).

Where it is running

• CEITEC MU (Central European Institute of Technology, Masaryk University) — Brno, South Moravian, Czechia (enrolling)

Full record on ClinicalTrials.gov

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