Alterations in Mast Cell and Macrophage Infiltration, as Well as Micro Vessel Density
Recruiting now
Conditions studied: Obesity
In brief
Obesity is a global health problem that has reached epidemic proportions, affecting more than one billion people worldwide and significantly increasing the risk of multiple comorbidities, including type 2 diabetes, cardiovascular diseases, and cancer (World Health Organization, 2024). Increasing evidence suggests that chronic low-grade inflammation associated with obesity plays a critical role in the development of obesity-related malignancies, including gastric cancer. Adipose tissue dysfunction in obesity leads to the recruitment and activation of various immune cells, such as macrophages and mast cells, which contribute to a pro-inflammatory microenvironment through the release of cytokines, growth factors, and angiogenic mediators.
Key facts
- Study ID
- NCT07448896
- Run by
- General Committee of Teaching Hospitals and Institutes, Egypt
- People needed
- 100
- Starts
- 2026-04-15
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2026-04-29
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients undergoing bariatric surgery (laparoscopic sleeve gastrectomy).
- BMI > 35 kg/m²
- All participants underwent preoperative evaluation, including blood tests and assessment by a multidisciplinary team (nutritionist, psychiatrist, endocrinologist, radiologist, anesthesiologist, and surgeon).
You may not qualify if…
- Patients with secondary causes of obesity, such as Cushing's syndrome or polycystic ovary syndrome (PCOS).
- Patients with malignant gastric conditions or previous gastric surgery.
- Patients with systemic inflammatory diseases, autoimmune disorders, or chronic infections that may influence immune cell infiltration.
- Patients with incomplete clinical data or poor-quality tissue samples.
- Patients taking anti-inflammatory, immunosuppressive, or corticosteroid therapy within the last 3 months before sampling.
Where it is running
- The surgical department of Medical Research Institute Hospital, Alexandria University — Alexandria, Alexandria Governorate, Egypt (enrolling)
Full record on ClinicalTrials.gov
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