Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma

Starting soon · Phase 2/Phase 3

Conditions studied: Melasma

In brief

In this study, the investigators evaluate the potential efficacy of TXA alone and microneedling assisted with glutathione alone versus combination of oral tranexamic acid and glutathione-assisted microneedling in the treatment of melasma

Key facts

Study ID

NCT07448415

Run by

Assiut University

People needed

42

Starts

2026-02-01

Expected to finish

2027-04-01

Last updated by the study team

2026-03-04

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• • female patients
• 18/50 years old
• facial melasma

You may not qualify if…

• pregnancy
• lactation.
• History of any bleeding,
• clotting disorder
• using anticoagulants
• Chronic systemic diseases
• patients with history of atypical parkinsonism
• use of neuroleptics,
• history of a seizure
• drug addiction
• Patients with signs of facial inflammation or infection.
• Patients on oral contraceptive pills
• patients with hormonal replacement therapy
• patients on isotretinoin at the time of the study or during the past 6 months.

Full record on ClinicalTrials.gov

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