EUS-guided CTCs + Multi-omics: Predicting Pancreatic Cancer Recurrence and Metastases

Starting soon

Conditions studied: CTCs, Pancreatic Cancer, Liver Metastases, Relapse, Borderline Resectable Pancreatic Cancer, Resectable Pancreatic Cancers, EUS

In brief

The investigators conduct a single-center, prospective, observational study to explore the value of EUS-guided portal vein circulating tumor cells (PV-CTCs) and their subtypes combined with multi-omics tests in the early warning of recurrence and metastasis of resectable pancreatic cancer(RPC) and borderline resectable pancreatic cancer (BRPC).

Key facts

Study ID: NCT07448376
Run by: Huazhong University of Science and Technology
People needed: 20
Starts: 2026-03-01
Expected to finish: 2027-12-30
Last updated by the study team: 2026-03-04

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients with solid masses (diameter > 1 cm) in the pancreatic area within the accessible range of endoscopic ultrasound, as indicated by clinical symptoms, laboratory tests, and imaging examinations (MRI, CT, B-ultrasound), who require biopsy to clarify the nature of the lesion.
Patients diagnosed with resectable pancreatic cancer, borderline resectable pancreatic cancer, locally advanced pancreatic cancer by imaging(CT/MRI).
Newly diagnosed pancreatic cancer patients who have not received radiotherapy or chemotherapy.
Signed informed consent form.
Patients must be able to comply with the trial requirements.

You may not qualify if…

Patients with other active malignant tumors
Patients with coagulation dysfunction (PLT 50,000/mm3, INR > 1.5; roughly estimated, INR > 1.5 is approximately equivalent to PT > 18 seconds)
Pregnant women
Patients with hemorrhagic diseases
Patients with a history of taking anticoagulant drugs such as aspirin and warfarin in the past week
Patients with absolute contraindications to EUS examination, a history of acute pancreatitis within the past 2 weeks, a history of gastric surgery, pregnancy, severe diseases, or a history of allergy to anesthetics
Patients whose EUS examination was terminated early due to esophageal stenosis, obstruction, large space-occupying lesions, rapid changes in the patient's heart rate or respiratory rate, patient intolerance, or a large amount of food residue, etc.
Patients with known hepatitis C virus infection
Patients with known human immunodeficiency virus (HIV) infection
Patients with imaging examinations, EUS results, etc., suggesting pancreatic cystic space-occupying lesions
Patients who have received radiotherapy or chemotherapy
Patients with incomplete pathological information, unable to make a clear diagnosis, or unable to sign the informed consent form

Where it is running

Tongji Hospital, Tongji Medical College, HUST — Wuhan, Hubei, China

Full record on ClinicalTrials.gov

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