Can Betamethasone Given After Birth Help Extremely Premature Babies Come Off Breathing Support Safely and Effectively?

Starting soon · Phase 2

Conditions studied: Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD)

In brief

The goal of this study is to determine if giving a steroid medication (specifically, betamethasone) after birth can help extremely premature babies (born before 28 weeks) come off breathing machines safely and reduce their risk of chronic lung disease associated with prematurity. Only babies who meet treatment criteria will receive this medication. Babies who do not meet treatment criteria will not receive medication. The main questions it aims to answer are: * Does betamethasone make it easier for babies to come off a breathing machine? * Does betamethasone cause any harmful side effects on growth or development? All babies in this study will: * Receive standard NICU care, with or without betamethasone * Have their progress, growth, and development followed over time

Key facts

Study ID

NCT07447739

Run by

Khang Nguyen

People needed

100

Starts

2026-04-01

Expected to finish

2029-03-01

Last updated by the study team

2026-03-03

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants born at less than 28 weeks gestation age
• Admitted to WMC NICU prior to day of life 35

You may not qualify if…

• Infants with major congenital or chromosomal abnormalities.
• Death prior to DOL 8.
• Previous exposure to postnatal steroids

Where it is running

• Maria Fareri Children's Hospital at Westchester Medical Center — Valhalla, New York, United States

Full record on ClinicalTrials.gov

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