Exercise With and Without Cognitive Training

Starting soon · Not applicable

Conditions studied: Multiple Sclerosis

In brief

This proposal aims to conduct a 10-week randomized controlled trial comparing walking and resistance training with and without computerized cognitive training in older Veterans with Multiple Sclerosis, followed by 12 months of fall tracking with sensors and fall calendars. The primary objectives of this proposed CDA2 are to provide critical preliminary data on 1) the feasibility of conducting a 10-week RCT, 2) preliminary treatment effects on gait, cognition, and falls, and 3) neuroinflammatory biomarkers. Dr. Katherine Hsieh will receive hands-on training in the design and conduct of clinical trials (Dr. Hackney), mechanisms underlying physical activity, cognitive rehabilitation, and falls (Drs. Twamley, Hackney, \& Kesar), fall detection technology (Prof. Sanford), and clinical problems faced by MS participants (Dr. Backus) to achieve her long-term career goal of becoming an independent falls prevention investigator.

Key facts

Study ID

NCT07447115

Run by

VA Office of Research and Development

People needed

30

Starts

2027-01-04

Expected to finish

2028-05-01

Last updated by the study team

2026-03-03

Who can join

Age: 55 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• US Veteran
• Diagnosis of Multiple Sclerosis
• Relapse free in the last 30 days
• Capable of standing unaided for at least 1 minute
• Expanded Disability Status Scale <6.5
• Ability to speak and understand English

You may not qualify if…

• Any neurological disorder other than MS
• Modified Telephone Interview for Cognitive Status <20
• Current participation in an exercise or cognitive rehabilitation study

Where it is running

• Atlanta VA Medical and Rehab Center, Decatur, GA — Decatur, Georgia, United States

Full record on ClinicalTrials.gov

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