A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Nausea and Vomiting, Obesity
In brief
The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms.
Key facts
- Study ID
- NCT07446439
- Run by
- Vanda Pharmaceuticals
- People needed
- 280
- Starts
- 2026-03-27
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-04-20
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Body Mass Index ≥ 25 and < 40 kg/m\^2
- No serious medical problems or chronic diseases, specifically no type I or type II diabetes
You may not qualify if…
- Another disorder that contributes to gastrointestinal symptoms
- History of intolerance and/or hypersensitivity to NK-1 receptor antagonists
- History of intolerance and/or hypersensitivity to GLP-1 receptor agonists
- Exposure to any investigational medication within the past 60 days
Where it is running
- Vanda Investigational Site — Tampa, Florida, United States (enrolling)
- Vanda Investigational Site — San Diego, California, United States (enrolling)
- Vanda Investigational Site — Los Angeles, California, United States (enrolling)
- Vanda Investigational Site — New York, New York, United States
- Vanda Investigational Site — Syosset, New York, United States
- Vanda Investigational Site — Plano, Texas, United States
- Vanda Investigational Site — San Antonio, Texas, United States
- Vanda Investigational Site — Burke, Virginia, United States
- Vanda Investigational Site — San Jose, California, United States
- Vanda Investigational Site — Hamilton, New Jersey, United States
Full record on ClinicalTrials.gov
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