Kidney Transplant Improvement Through New Exercise Training to Increase Capacity

Recruiting now · Not applicable

Conditions studied: Chronic Kidney Disease 5D, Chronic Kidney Disease Stage 5, Kidney Failure, Kidney Failure,Chronic, Renal Insufficiency Chronic, Chronic Kidney Disease Stage 4, Kidney Transplantation, Waiting List, Transplant Candidate, Exercise Theraphy

In brief

The goal of this clinical trial is to learn if a home-based exercise program can be safely and feasibly used to improve physical activity and physical function in adults waiting for a kidney transplant. The study will also learn how acceptable and useful this program is for participants. The main questions it aims to answer are: * Can a remote exercise program be delivered successfully to people on the kidney transplant waiting list? * Do participants follow the exercise program and wear a physical activity tracker as asked? * Is the program safe and well tolerated? Researchers will compare two groups to see if the exercise program leads to higher physical activity and better physical function: * Usual pre-transplant care with a physical activity tracker * Usual pre-transplant care plus an online exercise program Participants will: * Wear a wrist activity tracker to measure daily physical activity * Complete a one-week baseline period before being assigned to a study group * Be randomly assigned (like flipping a coin) to one of two groups * If assigned to the exercise group, take part in online exercise classes at home for 12 weeks with reminders and feedback, and then another 12 weeks without reminders and feedback * Answer questionnaires about their health, activity, and experience in the study This study may help researchers learn how to better support people waiting for kidney transplant through safe, home-based exercise programs.

Key facts

Study ID

NCT07446296

Run by

University of Pennsylvania

People needed

60

Starts

2026-03-24

Expected to finish

2028-05-01

Last updated by the study team

2026-05-06

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• be at least 60 years old
• receive transplant care at Penn Medicine
• be on the kidney transplant waiting list
• speak and comprehend English
• be able to walk
• have at least one physical function limitation OR at least one frailty metric
• have access to a device capable of connecting to the Internet and downloading an application
• be able to provide written informed consent
• be cleared for participant via the Physical Activity Readiness Questionnaire (PARQ) verified against medical record or via written medical clearance from a clinician

You may not qualify if…

• Have had a myocardial infarction or a stroke in the 3 months immediately prior to enrollment
• Be unable to self-monitor with study devices (i.e., have a condition such as dementia)
• Not cleared by PARQ or receive written medical clearance to exercise
• Participate in another physical activity study
• Have any other reason they do not expect to be able to complete the study

Where it is running

• Perelman Center for Advanced Medicine — Philadelphia, Pennsylvania, United States (enrolling)

Full record on ClinicalTrials.gov

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