Comparison of Accelerated Intermittent Theta Burst Stimulation vs High Frequency Transcranial Magnetic Stimulation (Hf-rTMS) on Cognitivesymptoms in Treatment-resistant Schizophrenia
Starting soon · Not applicable · Has a placebo group
Conditions studied: Psychosis, Schizophrenia Disorder
In brief
This randomized, double-blind, sham-controlled trial compares three brain stimulation approaches-accelerated intermittent theta burst stimulation (aITBS), high-frequency repetitive transcranial magnetic stimulation (HF-rTMS), and sham stimulation-for treating cognitive deficits in treatment-resistant schizophrenia. Ninety patients receiving clozapine will be randomized 1:1:1 to receive 20 sessions over 4 weeks targeting the dorsolateral prefrontal cortex. The primary outcome is change in cognitive function measured by B-CATS score at 2, 4, and 12 weeks. Secondary outcomes include social cognition, symptom severity, brain metabolism (FDG-PET), and inflammatory biomarkers.
Key facts
- Study ID
- NCT07445620
- Run by
- All India Institute of Medical Sciences, Bhubaneswar
- People needed
- 90
- Starts
- 2026-09-15
- Expected to finish
- 2029-12-14
- Last updated by the study team
- 2026-08-10
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed with treatment-resistant schizophrenia according to TRIIP Consensus criteria
- Age: 18-60 years
- Currently receiving clozapine treatment for at least 6 months
- Attending psychiatry outpatient department at AIIMS Bhubaneswar
You may not qualify if…
- Currently receiving or recently received ECT/rTMS/tDCS
- Co-morbid psychiatric, major medical, or neurological disorders
- History of withdrawal seizures, delirium tremens, or significant head injury
- Presence of pacemaker or metal in any part of body (excluding mouth)
- Pregnant or lactating women
Where it is running
- AIIMS Bhubaneswar — Bhubaneswar, Odisha, India
Full record on ClinicalTrials.gov
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