Comparison of Radiofrequency Ablation With Concomitant or Staged Treatment for Tributary Varicose Veins

Starting soon · Not applicable

Conditions studied: Varicose Veins of Lower Limb

In brief

The purpose of this clinical trial is to know which is better to treat the branch vein at the same time or in stages during radiofrequency ablation. The main questions it aims to answer are: Does the patient who did not treat the branch vein in the first stage of operation need to intervene again? Are there any differences in patients' indexes between the two surgical strategies? Participants will: Radiofrequency ablation with or without foam sclerosing agent therapy One week, three months and six months after operation, go to the clinic for a reexamination. Record their symptoms

Key facts

Study ID

NCT07445425

Run by

Sir Run Run Shaw Hospital

People needed

206

Starts

2026-03-01

Expected to finish

2026-12-01

Last updated by the study team

2026-03-03

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• aged between 18 and 80 years; primary unilateral lower limb GSV varicose; hemodynamic classification I and III involvement in tributary veins, tributary veins originating within 15 cm inferior to the knee joint; clinical grade C2-C4; primary trunk diameter of GSV in thigh segment≥3mm to ≤ 15 mm; agree to participate in this study and voluntarily sign an informed consent form.

You may not qualify if…

• Body Mass Index (BMI) ≥35kg/m2; severe tortuosity or tight adherence of the trunk of the GSV to the skin in the thigh; history of previous varicose vein surgery on the ipsilateral lower limb (investigator allows to be controlled); previous deep vein thrombosis and/or calf muscle venous thrombosis; uncorrectable coagulation disorders or significant blood abnormalities (platelets≤30×109/L); allergy to lidocaine or sclerosing agents; ankle-brachial index (ABI) <0.6 and/or absolute ankle pressure <60mmHg; pregnancy or lactation, or intend to have a child in the next year; participation in other clinical trials; anterior saphenous vein start diameter>3.5mm; any other patients investigator considers improper to participate in this study.

Where it is running

• The First Affiliated Hospital of Bengbu Medical University — Bengbu, Anhui, China
• Peking University International Hospital — Beijing, Beijing Municipality, China
• Peking University Third Hospital — Beijing, Beijing Municipality, China
• Guangxi Zhuang Autonomous Region People's Hospital — Nanning, Guangxi, China
• The First Affiliated Hospital of Guangxi University of Chinese Medicine — Nanning, Guangxi, China
• Hainan Provincial Hospital of Traditional Chinese Medicine — Haikou, Hainan, China
• Zhengzhou Central Hospital — Zhengzhou, Henan, China
• Zhoukou Central Hospital — Zhoukou, Henan, China
• The First People's Hospital of Chenzhou — Chenzhou, Hunan, China
• Huai'an First People's Hospital — Huai'an, Jiangsu, China
• Jiangsu Province Hospital of Traditional Chinese Medicine — Nanjing, Jiangsu, China
• The Second Affiliated Hospital of Nanchang University — Nanchang, Jiangxi, China
• The First Affiliated Hospital of Dalian Medical University — Dalian, Liaoning, China
• The First Affiliated Hospital of China Medical University — Shenyang, Liaoning, China
• Dezhou People's Hospital — Dezhou, Shandong, China
• Yantai Yuhuangding Hospital — Yantai, Shandong, China
• Zibo First Hospital — Zibo, Shandong, China
• Sir Run Run Shaw Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
• Hangzhou Third People's Hospital — Hangzhou, Zhejiang, China
• The Second Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China
• Affiliated Hospital of Shaoxing University — Shaoxing, Zhejiang, China

Full record on ClinicalTrials.gov

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