Serum Bicarbonate Changes During Laparoscopic Bariatric Surgery
Starting soon
Conditions studied: Acid Base Disorder
In brief
Pneumoperitoneum during laparoscopic bariatric surgery induces carbon dioxide absorption and may lead to perioperative alterations in acid-base balance. Serum bicarbonate (HCO₃-) plays a central role in metabolic compensation; however, the clinical relevance of perioperative bicarbonate changes remains insufficiently defined. This prospective observational study aims to evaluate the association between pneumoperitoneum duration and perioperative serum bicarbonate change (ΔHCO₃-), and to investigate whether ΔHCO₃- is associated with early discharge readiness at 48 hours (DR-48) following laparoscopic bariatric surgery. Patients undergoing laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass will be enrolled consecutively. No alteration of routine clinical care will occur.
Key facts
- Study ID
- NCT07445230
- Run by
- Istinye University
- People needed
- 85
- Starts
- 2026-03-01
- Expected to finish
- 2026-05-15
- Last updated by the study team
- 2026-03-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged ≥18 years
- ASA physical status I-III
- Scheduled for elective laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass)
- Provided written informed consent
You may not qualify if…
- Age <18 years
- ASA physical status IV or higher
- Chronic obstructive pulmonary disease (COPD), asthma, or other severe chronic respiratory disease
- Known chronic metabolic acidosis or renal failure
- Major intraoperative complications (e.g., severe bleeding, conversion to open surgery)
- Postoperative reoperation, intensive care requirement, or complications preventing standard recovery evaluation
Where it is running
- Istinye Üniversity — Istanbul, Merkez Mahallesi, Turkey (Türkiye)
Full record on ClinicalTrials.gov
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