Vericiguat in Decompensated Cardiac Failure: Clinical Insights on Addition to Guidelines Derived Medical Therapy-VERCIG Trial
Recruiting now · Phase 1
Conditions studied: Decompensated Heart Failure
In brief
This study will compare the outcomes of Vericuguat and placebo in patient with decompensated heart failure . This study will carry out after approval from IERB. Seventy patients fulfilling the inclusion criteria will be enrolled from emergency department. Informed consent will be taken from attendants. A detailed history including name, age, gender, duration of heart failure, history of alcoholism, smoking, diabetes, hypertension, EF at baseline and NYHA class will be noted. Patients will be randomly divided in two groups by using lottery method. Outcomes will be assessed at in terms of hospitalization for heart failure, death from cardiovascular event and side effects.
Key facts
- Study ID
- NCT07444398
- Run by
- Khawaja Danish Ali
- People needed
- 130
- Starts
- 2026-01-01
- Expected to finish
- 2026-03-31
- Last updated by the study team
- 2026-03-02
Who can join
Age: 25 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients diagnosed with decompensated heart failure (patients with left ventricular ejection fraction ≤45% presenting with NYHA functional class III-IV symptoms or worsening class II symptoms. Along with elevated natriuretic peptide levels defined as NT-proBNP >1000 pg/mL in patients with sinus rhythm and >1600 pg/mL in patients with atrial fibrillation in the absence of alternative causes of biomarker elevation)
You may not qualify if…
- Patients with blood pressure <100 mmHg;
- concurrent or anticipated use of long-acting nitrates, soluble guanylate cyclase stimulators, or phosphodiesterase type 5 inhibitors
- use of intravenous inotropes or implantable left ventricular assist devices (on medical record)
Where it is running
- Armed Forces Institute of Cardiology. Pakistan — Rawalpindi, Punjab Province, Pakistan (enrolling)
Full record on ClinicalTrials.gov
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