Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock

Starting soon

Conditions studied: Aging, Obesity & Overweight

In brief

This study examines whether routine treatment with semaglutide or tirzepatide, prescribed with lifestyle coaching in a real-world weight-management program, is associated with changes in biological age measured by the LinAge2 clinical aging clock over 6 months.

Key facts

Study ID

NCT07444073

Run by

National University of Singapore

People needed

440

Starts

2026-06-01

Expected to finish

2027-12-31

Last updated by the study team

2026-07-01

Who can join

Age: 40 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 40-89 years, who are newly enrolled in the NOVI OP+ weight management program.
• BMI of ≥ 30 kg/m2 (obesity); OR
• BMI of ≥ 27 kg/m2 to < 30 kg/m2 (overweight) in the presence of at least one weight-related comorbid condition e.g. dysglycemia (prediabetes or type 2 diabetes mellitus), hypertension, dyslipidemia, obstructive sleep apnea or cardiovascular disease.

You may not qualify if…

• Pregnancy or lactation.
• Non-ambulatory status, total blindness, complete hearing loss, or inability to speak.
• Medical history of, or self-reported, psychiatric illness, congenital or irreversible neurodegenerative diseases, cognitive impairment, or eating disorders that may affect adherence or assessment outcomes.
• On GLP-1 RA, sulfonylurea or insulin medications for the past 3 months.
• Active cancer on chemotherapy or immunotherapy.
• Known hypersensitivity or contraindications to GLP-1 RAs.
• Any condition, in the opinion of the attending clinician, that would jeopardize participant safety or interfere with study compliance.

Where it is running

• NOVI Health (T3 Health PTE LTD) — Singapore, Singapore
• National University of Singapore — Singapore, Singapore

Full record on ClinicalTrials.gov

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