MRI-Based Lesion Differentiation in Older Patients With Multiple Sclerosis

Recruiting now

Conditions studied: Multiple Sclerosis (MS), Cerebral Small Vessel Diseases

In brief

This study investigates whether an advanced MRI technique called Quantitative Susceptibility Mapping (QSM) can improve the differentiation of white matter lesions in people aged 50-70 years with multiple sclerosis (MS). In older individuals with MS, white matter changes seen on MRI may be related to MS or to other types of white matter changes, most commonly age-related changes or chronic small vessel disease. These conditions can appear similar on conventional MRI scans, making interpretation challenging. Participants will undergo routine clinical MRI, including a short additional QSM sequence, as well as brief cognitive and physical assessments. A comparison group with cerebral small vessel disease will also be included. The goal of the study is to determine whether QSM can provide more precise lesion characterization and support more accurate clinical interpretation of MRI findings in older patients with MS.

Key facts

Study ID
NCT07444047
Run by
Oslo University Hospital
People needed
1000
Starts
2026-05-11
Expected to finish
2031-12-31
Last updated by the study team
2026-06-01

Who can join

Age: 50 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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