Voice Analysis to Detect Pulmonary Arterial Pressure Changes in Heart Failure
Recruiting now
Conditions studied: Heart Failure
In brief
VAPP-HF is a prospective, multi-center, observational study assessing whether daily voice recordings analyzed by a machine learning algorithm can detect changes in pulmonary arterial (PA) pressure in heart failure patients with implanted PA pressure sensors (e.g., CardioMEMS, Cordella). Patients across three sites in Germany and the United States provide daily voice recordings via a mobile app for 12 weeks while continuing standard PA pressure monitoring and heart failure care. Voice data is analyzed retrospectively after study completion; no clinical decisions are based on voice analysis during the study. The primary endpoint is the sensitivity and specificity of the AI-based voice analysis in detecting PA pressure changes at defined thresholds.
Key facts
- Study ID
- NCT07443670
- Run by
- Noah Labs
- People needed
- 60
- Starts
- 2024-12-12
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2026-03-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older
- Successful implantation of a PA pressure sensor and monitored by a participating study center
- Willingness to record a short predefined text daily for 3 months using a smartphone or tablet
- Ability to comfortably read aloud the study passage in English or German
- Written informed consent obtained
You may not qualify if…
- Pregnant, breastfeeding, or unwilling to practice birth control during participation
- Condition that in the opinion of the investigator would compromise patient safety or data quality
- Pathological voice changes due to surgery or injury
- Planned invasive cardiac procedures during the study period
- COPD requiring home oxygen therapy
- Chronic kidney disease requiring dialysis
- Cognitive dysfunction limiting ability to perform daily voice recording
- Inability to read English or German
- Physical inability to use the recording device
Where it is running
- University of California, San Francisco (UCSF) — San Francisco, California, United States (enrolling)
- BG Klinikum Unfallkrankenhaus Berlin, Dept. of Cardiology — Berlin, State of Berlin, Germany
- University Hospital Frankfurt, Dept. of Cardiology and Angiology — Frankfurt, Germany
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.