FCI-Glioblastoma Study

Starting soon

Conditions studied: Glioblastom WHO Grade 4

In brief

The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can tell the difference between tumour growth (progression) and 'pseudo-progression' (which looks like tumour but is not cancerous tissue) in patients with glioblastoma. The main question it aims to answer is: • Can FCI differentiate glioblastoma progression from pseudo-progression? Participants will undergo a standard MRI scan and an FCI scan, three times during the study. One before starting adjuvant chemotherapy, another one after three cycles and one at the end of treatment.

Key facts

Study ID

NCT07443176

Run by

University of Aberdeen

People needed

18

Starts

2026-05-01

Expected to finish

2027-12-01

Last updated by the study team

2026-04-30

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients scheduled to have standard adjuvant temozolomide treatment for glioblastoma, within four weeks following radical radiotherapy with concomitant temozolomide
• 18 to 70 years old
• Life expectancy at least 12 weeks
• Able to undergo MRI scans lasting up to 1 hour each
• On stable or reducing dose of steroids for at least 5 days
• Able to provide informed consent
• Able to understand written and spoken English

You may not qualify if…

• Previous treatment for glioblastoma other than surgery and chemoradiation.
• Previous radiotherapy to brain and/or prior chemotherapy for lower grade glioma.
• Planned additional treatment with Tumor-Treating Fields
• Previous cytotoxic wafers or implants at the time of neurosurgery
• Uncontrolled intercurrent illness
• Being pregnant or nursing
• Conventional MRI contraindications
• Known allergy to contrast agent
• Unable to provide informed consent

Where it is running

• University of Aberdeen — Aberdeen, United Kingdom

Full record on ClinicalTrials.gov

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