Impact of Exercise Intensity on Cardiac Health in Young Adult Survivors of Childhood Cancer: The PULSE Trial

Running, not enrolling · Not applicable

Conditions studied: Childhood Cancer Survivors, Cardiotoxicity, Cardiovascular Diseases, Anthracycline-induced Cardiotoxicity

In brief

This trial aims to evaluate the impact of exercise intensity on cardiac health in young adult survivors of childhood cancer previously treated with anthracyclines.

Key facts

Study ID

NCT07442578

Run by

Dana-Farber Cancer Institute

People needed

20

Starts

2026-03-04

Expected to finish

2028-03-04

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older, up to 39. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Current age at study initiation 18-39 years.
• Cancer diagnosis at age ≤ 18 years.
• Previous exposure to any dose of anthracyclines.
• Are ≥2 years post-treatment and in remission without relapse after cancer directed therapy.
• Eastern Cooperative Oncology Group Performance Status = 0
• Oncology survivorship provider clearance to participate in exercise
• No self-reported comorbidities or contraindications that prohibit the undertaking of high intensity exercise (e.g., severe valvular heart disease)
• Sedentary (i.e., currently participates in ≤ 60 minutes of structured high or moderate intensity exercise/week) determined by self-report during screening using the Godin Leisure Time Exercise Questionnaire
• Speak English
• Willing to travel to Dana-Farber Cancer Institute for necessary data collection

You may not qualify if…

• Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise.
• Patients who are pregnant.
• Participate in more than 60 minutes of structured moderate-to-vigorous exercise per week over the last month.
• Patients receiving treatment for other active malignancies (except basal cell carcinoma).
• Subjects who in the opinion of the investigators, may not be able to comply with the safety monitoring requirements of the study.
• Unable to travel to DFCI Longwood campus for necessary data collection.

Where it is running

• Dana-Farber Cancer Institute — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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