Perioperative Sepsis. An Epigenetic Perspective
Recruiting now
Conditions studied: Sepsis Abdominal
In brief
This single-center, prospective, observational study evaluates the impact of perioperative sepsis on inflammatory response, coagulation abnormalities, cardiac dysfunction, and microRNA expression in adult patients undergoing major abdominal surgery. Forty patients are enrolled and classified into septic and non-septic groups according to international sepsis definitions based on SOFA score criteria. Clinical, biochemical, echocardiographic, and molecular parameters, including selected microRNAs, are assessed preoperatively and within the first 24 hours postoperatively. The study aims to characterize pathophysiological differences associated with perioperative sepsis and to explore the potential prognostic value of microRNAs as early biomarkers of postoperative sepsis.
Key facts
- Study ID
- NCT07442552
- Run by
- Carol Davila University of Medicine and Pharmacy
- People needed
- 40
- Starts
- 2026-01-20
- Expected to finish
- 2026-04-10
- Last updated by the study team
- 2026-03-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Undergoing major abdominal surgery (elective or emergency)
- Ability to provide written informed consent
- Availability of biological samples in the preoperative period and within 24 hours postoperatively
- Preoperative hemodynamic stability
You may not qualify if…
- Surgical reintervention within 3 months after the index procedure
- Multiple surgical procedures during the same hospitalization
- Active chronic infections (HIV, active viral hepatitis, tuberculosis)
- Autoimmune or systemic inflammatory diseases
- Chronic immunosuppressive therapy or long-term corticosteroid use
- Severe hepatic failure (Child-Pugh class C)
- End-stage renal disease requiring dialysis
- Severe pre-existing cardiac disease (NYHA class III-IV heart failure)
- Pregnancy
- Refusal or inability to provide informed consent
Where it is running
- Institutul Clinic Fundeni — Bucharest, Sector 2, Romania (enrolling)
Full record on ClinicalTrials.gov
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